I've used the weighted scores for the file with summed-up experimental and prediction values (where the total score was divided by the total number of genes [31]).
The normalized scores are the total score divided by the highest total score. I wasn't sure if it would be useful to try those scores instead.
Due to the extremely high number of experimentally validated interactions hsa-miR-16-5p produces the highest number in all of the variations (with different factors assigned to the experimentally validate).
After assigning a factor of 5 or higher to the experimentally validated values, there are little to no changes in the rankings of miRNAs.
SMLG (Statistical Machine Learning Group) Discussion Forum
Changwon Yoo, S.M., Ph.D., PI
"master" miRNA for Zinc metabolism
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"master" miRNA for Zinc metabolism
by nbori003 » Tue Jun 13, 2023 3:42 pm
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miRNA experimented + predicted.xlsx- (206.98 KiB) Downloaded 48 times
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- TargetScan_Matrix.xlsx
- Predicted values
- (178.05 KiB) Downloaded 53 times
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- TarBase_Matrix.xlsx
- Experimentally validated
- (139.34 KiB) Downloaded 46 times
- nbori003
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Re: "master" miRNA for Zinc metabolism
by nbori003 » Thu Jun 29, 2023 2:12 pm
I've added the normalized values from the miRabel and mirWalk databases
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- mirWalk_Matrix.xlsx
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- miRabel_Matrix.xlsx
- (307.88 KiB) Downloaded 31 times
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- miRNA experimented + 3 predicted.xlsx
- (127.26 KiB) Downloaded 31 times
- nbori003
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- Joined: Thu Aug 25, 2022 2:24 pm
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