Pulmonary Arterial Hypertension - PAH

Gene-gene gene-environment interactions. Hamza Assaggaf <hassa001@fiu.edu> will be the moderator of this forum.

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Re: Pulmonary Arterial Hypertension - PAH

Postby cwyoo » Mon Jul 14, 2014 11:45 am

meninonas wrote:Professor,

Earlier today, I finished running Banjo for the PAH data. Unfortunately, neither of the runs (1, 2, 4, and 6 hours) produced three equal top BNs. I still strongly believe that the logistic regression needs to be run so the BN can be done with the relevant proteins. I think this will also help with the production of a consistent BN.

I have sent the results to Hamza. He should post at another time.


Hamza/Luis, please normalize the log scores, so we know the significance of the liklihood of the structure. There is a perl script that is posted as a public project in Git and the documentation is posted in:

Manuscripts & Documentation ‹ Implemented Modules Documentation ‹ How to run scripts/programs
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Re: Pulmonary Arterial Hypertension - PAH

Postby Hamza » Mon Jul 14, 2014 5:12 pm

Banjo 1hour run
Attachments
top.graph.2014.07.13.14.11.54.jpg
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top.graph.2014.07.13.14.11.29.jpg (484.95 KiB) Viewed 2361 times
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Re: Pulmonary Arterial Hypertension - PAH

Postby Hamza » Mon Jul 14, 2014 5:13 pm

Banjo 2 hours run
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top.graph.2014.07.12.23.46.29.jpg
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Re: Pulmonary Arterial Hypertension - PAH

Postby Hamza » Mon Jul 14, 2014 5:33 pm

Banjo 4 hours run
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top.graph.2014.07.12.19.43.09.jpg
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Re: Pulmonary Arterial Hypertension - PAH

Postby Hamza » Mon Jul 14, 2014 5:34 pm

Banjo, 6 hours run
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top.graph.2014.07.11.17.44.51.jpg
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Re: Pulmonary Arterial Hypertension - PAH

Postby Hamza » Mon Jul 14, 2014 5:39 pm

The best score among the last 4 run in Banjo, is the second map of the 6 hours run with 21087.
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Re: Pulmonary Arterial Hypertension - PAH

Postby meninonas » Sat Jul 19, 2014 12:00 am

Dr. Yoo,

Here's the results from all four runs separated by runs and then placed all together.

For 1 Hour:

Total score -21149.1337926528
Log score -21149.1338 is 99.9992652870493 % of total score
Total score -21149.1337926528
Log score -21160.9560 is 0.000733973846712013 % of total score
Total score -21149.1337926528
Log score -21167.8566 is 7.39244468246854e-07 % of total score

For 2 Hours:

Total score -21135.019289767
Log score -21135.0371 is 98.2347431779535 % of total score
Total score -21135.019289767
Log score -21139.3540 is 1.31056711136369 % of total score
Total score -21135.019289767
Log score -21140.4126 is 0.454689710766322 % of total score

For 4 Hours:

Total score -21130.5446770023
Log score -21130.5821 is 96.3268588752667 % of total score
Total score -21130.5446770023
Log score -21133.8488 is 3.67314112466307 % of total score
Total score -21130.5446770023
Log score -21158.0879 is 1.09176769177344e-10 % of total score

For 6 Hours:

Total score -21087.1786
Log score -21158.7797 is 8.01747052150605e-30 % of total score
Total score -21087.1786
Log score -21087.1786 is 100 % of total score
Total score -21087.1786
Log score -21139.1145 is 2.78307696859982e-21 % of total score

For all 12 logs scores from all 4 runs:

Total score -21087.1786
Log score -21149.1338 is 1.23936296640508e-25 % of total score
Total score -21087.1786
Log score -21160.9560 is 9.09666687363709e-31 % of total score
Total score -21087.1786
Log score -21167.8566 is 9.16198948497297e-34 % of total score
Total score -21087.1786
Log score -21135.0371 is 1.64178974196851e-19 % of total score
Total score -21087.1786
Log score -21139.3540 is 2.19034077963681e-21 % of total score
Total score -21087.1786
Log score -21140.4126 is 7.59919432539741e-22 % of total score
Total score -21087.1786
Log score -21130.5821 is 1.4128610569109e-17 % of total score
Total score -21087.1786
Log score -21133.8488 is 5.38752961756428e-19 % of total score
Total score -21087.1786
Log score -21158.0879 is 1.60133536265061e-29 % of total score
Total score -21087.1786
Log score -21158.7797 is 8.01747052150605e-30 % of total score
Total score -21087.1786
Log score -21087.1786 is 100 % of total score
Total score -21087.1786
Log score -21139.1145 is 2.78307696859982e-21 % of total score
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Re: Pulmonary Arterial Hypertension - PAH

Postby cwyoo » Sat Jul 19, 2014 9:13 pm

meninonas wrote:Dr. Yoo,

Here's the results from all four runs separated by runs and then placed all together.

For 1 Hour:

Total score -21149.1337926528
Log score -21149.1338 is 99.9992652870493 % of total score
Total score -21149.1337926528
Log score -21160.9560 is 0.000733973846712013 % of total score
Total score -21149.1337926528
Log score -21167.8566 is 7.39244468246854e-07 % of total score

For 2 Hours:

Total score -21135.019289767
Log score -21135.0371 is 98.2347431779535 % of total score
Total score -21135.019289767
Log score -21139.3540 is 1.31056711136369 % of total score
Total score -21135.019289767
Log score -21140.4126 is 0.454689710766322 % of total score

For 4 Hours:

Total score -21130.5446770023
Log score -21130.5821 is 96.3268588752667 % of total score
Total score -21130.5446770023
Log score -21133.8488 is 3.67314112466307 % of total score
Total score -21130.5446770023
Log score -21158.0879 is 1.09176769177344e-10 % of total score

For 6 Hours:

Total score -21087.1786
Log score -21158.7797 is 8.01747052150605e-30 % of total score
Total score -21087.1786
Log score -21087.1786 is 100 % of total score
Total score -21087.1786
Log score -21139.1145 is 2.78307696859982e-21 % of total score

For all 12 logs scores from all 4 runs:

Total score -21087.1786
Log score -21149.1338 is 1.23936296640508e-25 % of total score
Total score -21087.1786
Log score -21160.9560 is 9.09666687363709e-31 % of total score
Total score -21087.1786
Log score -21167.8566 is 9.16198948497297e-34 % of total score
Total score -21087.1786
Log score -21135.0371 is 1.64178974196851e-19 % of total score
Total score -21087.1786
Log score -21139.3540 is 2.19034077963681e-21 % of total score
Total score -21087.1786
Log score -21140.4126 is 7.59919432539741e-22 % of total score
Total score -21087.1786
Log score -21130.5821 is 1.4128610569109e-17 % of total score
Total score -21087.1786
Log score -21133.8488 is 5.38752961756428e-19 % of total score
Total score -21087.1786
Log score -21158.0879 is 1.60133536265061e-29 % of total score
Total score -21087.1786
Log score -21158.7797 is 8.01747052150605e-30 % of total score
Total score -21087.1786
Log score -21087.1786 is 100 % of total score
Total score -21087.1786
Log score -21139.1145 is 2.78307696859982e-21 % of total score


Good job! It seems we can use only the highest scoring structure.
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Re: Pulmonary Arterial Hypertension - PAH

Postby Hamza » Thu Jul 24, 2014 2:23 pm

I applied linear and logistic regression for PAH data. Linear regression run went fine, but logistic regression had a mission output in block 1.
Attachments
pah-binary logistic regression jeddah.pdf
Logistic Regression
(23.51 KiB) Downloaded 152 times
pah-linear jeddah.doc
Linear Regression
(1.11 MiB) Downloaded 141 times
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Re: Pulmonary Arterial Hypertension - PAH

Postby cwyoo » Thu Jul 24, 2014 2:35 pm

Hamza wrote:I applied linear and logistic regression for PAH data. Linear regression run went fine, but logistic regression had a mission output in block 1.


Please look into an option to use forward selection backward elimination option in logistic regression.
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