Data Repository

DREAM 3 Challenge 4

Postby meninonas » Thu Nov 13, 2014 1:02 am

Dr. Yoo,

The goal of the in silico challenges is the reverse engineering of gene networks from steady state and time series data and to predict the directed unsigned network topology from the given in silico generated gene expression datasets. There are three in-silico challenges corresponding to gene networks with 10, 50, and 100 genes.

For every network, the following experiments are simulated:

Heterozygous knock-down. The files -heterozygous contain the steady state levels for the wild-type and the heterozygous knock-down strains for each gene.

Null-mutants. The files -null-mutants contain the steady state levels for the wild-type and the null-mutant strains for each gene.

Trajectories. The files -trajectories contain time courses of the network recovering from several external perturbations. For the networks of size 10, we are given 4 perturbations (each one with 21 time points).

The Gold Standard simply states the presence of a relationship, not the direction.
Attachments
InSilicoSize10-Yeast2-trajectories.xlsx
(25.34 KiB) Downloaded 242 times
InSilicoSize10-Yeast2-null-mutants.xlsx
(13.36 KiB) Downloaded 247 times
InSilicoSize10-Yeast2-heterozygous.xlsx
(13.33 KiB) Downloaded 244 times
meninonas
 
Posts: 137
Joined: Tue Jun 24, 2014 3:25 pm

Re: Data Repository

Postby meninonas » Thu Nov 13, 2014 1:03 am

Dr. Yoo,

The goal of the in silico challenges is the reverse engineering of gene networks from steady state and time series data and to predict the directed unsigned network topology from the given in silico generated gene expression datasets. There are three in-silico challenges corresponding to gene networks with 10, 50, and 100 genes.

For every network, the following experiments are simulated:

Heterozygous knock-down. The files -heterozygous contain the steady state levels for the wild-type and the heterozygous knock-down strains for each gene.

Null-mutants. The files -null-mutants contain the steady state levels for the wild-type and the null-mutant strains for each gene.

Trajectories. The files -trajectories contain time courses of the network recovering from several external perturbations. For the networks of size 10, we are given 4 perturbations (each one with 21 time points).

The Gold Standard simply states the presence of a relationship, not the direction.
Attachments
InSilicoSize10-Yeast3-trajectories.xlsx
(25.89 KiB) Downloaded 224 times
InSilicoSize10-Yeast3-null-mutants.xlsx
(13.23 KiB) Downloaded 236 times
InSilicoSize10-Yeast3-heterozygous.xlsx
(13.28 KiB) Downloaded 248 times
meninonas
 
Posts: 137
Joined: Tue Jun 24, 2014 3:25 pm

Re: Data Repository

Postby meninonas » Thu Nov 13, 2014 1:05 am

Dr. Yoo,

The goal of the in silico challenges is the reverse engineering of gene networks from steady state and time series data and to predict the directed unsigned network topology from the given in silico generated gene expression datasets. There are three in-silico challenges corresponding to gene networks with 10, 50, and 100 genes.

For every network, the following experiments are simulated:

Heterozygous knock-down. The files -heterozygous contain the steady state levels for the wild-type and the heterozygous knock-down strains for each gene.

Null-mutants. The files -null-mutants contain the steady state levels for the wild-type and the null-mutant strains for each gene.

Trajectories. The files -trajectories contain time courses of the network recovering from several external perturbations. For the networks of size 50, the same number of time courses as in the DREAM2 in silico challenge are provided (23 different perturbations).

The Gold Standard simply states the presence of a relationship, not the direction.
Attachments
InSilicoSize50-Ecoli1-trajectories.xlsx
(459.95 KiB) Downloaded 229 times
InSilicoSize50-Ecoli1-null-mutants.xlsx
(88.5 KiB) Downloaded 228 times
InSilicoSize50-Ecoli1-heterozygous.xlsx
(88.31 KiB) Downloaded 228 times
meninonas
 
Posts: 137
Joined: Tue Jun 24, 2014 3:25 pm

DREAM 3 Challenge 4

Postby meninonas » Thu Nov 13, 2014 1:06 am

Dr. Yoo,

The goal of the in silico challenges is the reverse engineering of gene networks from steady state and time series data and to predict the directed unsigned network topology from the given in silico generated gene expression datasets. There are three in-silico challenges corresponding to gene networks with 10, 50, and 100 genes.

For every network, the following experiments are simulated:

Heterozygous knock-down. The files -heterozygous contain the steady state levels for the wild-type and the heterozygous knock-down strains for each gene.

Null-mutants. The files -null-mutants contain the steady state levels for the wild-type and the null-mutant strains for each gene.

Trajectories. The files -trajectories contain time courses of the network recovering from several external perturbations. For the networks of size 50, the same number of time courses as in the DREAM2 in silico challenge are provided (23 different perturbations).

The Gold Standard simply states the presence of a relationship, not the direction.
Attachments
InSilicoSize50-Ecoli2-trajectories.xlsx
(460.89 KiB) Downloaded 258 times
InSilicoSize50-Ecoli2-null-mutants.xlsx
(88.5 KiB) Downloaded 221 times
InSilicoSize50-Ecoli2-heterozygous.xlsx
(88.65 KiB) Downloaded 239 times
meninonas
 
Posts: 137
Joined: Tue Jun 24, 2014 3:25 pm

Re: Data Repository

Postby meninonas » Thu Nov 13, 2014 1:07 am

Dr. Yoo,

The goal of the in silico challenges is the reverse engineering of gene networks from steady state and time series data and to predict the directed unsigned network topology from the given in silico generated gene expression datasets. There are three in-silico challenges corresponding to gene networks with 10, 50, and 100 genes.

For every network, the following experiments are simulated:

Heterozygous knock-down. The files -heterozygous contain the steady state levels for the wild-type and the heterozygous knock-down strains for each gene.

Null-mutants. The files -null-mutants contain the steady state levels for the wild-type and the null-mutant strains for each gene.

Trajectories. The files -trajectories contain time courses of the network recovering from several external perturbations. For the networks of size 50, the same number of time courses as in the DREAM2 in silico challenge are provided (23 different perturbations).

The Gold Standard simply states the presence of a relationship, not the direction.
Attachments
InSilicoSize50-Yeast1-trajectories.xlsx
(460.46 KiB) Downloaded 241 times
InSilicoSize50-Yeast1-null-mutants.xlsx
(86.64 KiB) Downloaded 236 times
InSilicoSize50-Yeast1-heterozygous.xlsx
(86.62 KiB) Downloaded 233 times
meninonas
 
Posts: 137
Joined: Tue Jun 24, 2014 3:25 pm

DREAM 3 Challenge 4

Postby meninonas » Thu Nov 13, 2014 1:08 am

Dr. Yoo,

The goal of the in silico challenges is the reverse engineering of gene networks from steady state and time series data and to predict the directed unsigned network topology from the given in silico generated gene expression datasets. There are three in-silico challenges corresponding to gene networks with 10, 50, and 100 genes.

For every network, the following experiments are simulated:

Heterozygous knock-down. The files -heterozygous contain the steady state levels for the wild-type and the heterozygous knock-down strains for each gene.

Null-mutants. The files -null-mutants contain the steady state levels for the wild-type and the null-mutant strains for each gene.

Trajectories. The files -trajectories contain time courses of the network recovering from several external perturbations. For the networks of size 50, the same number of time courses as in the DREAM2 in silico challenge are provided (23 different perturbations).

The Gold Standard simply states the presence of a relationship, not the direction.
Attachments
InSilicoSize50-Yeast2-trajectories.xlsx
(462.18 KiB) Downloaded 253 times
InSilicoSize50-Yeast2-null-mutants.xlsx
(88.82 KiB) Downloaded 256 times
InSilicoSize50-Yeast2-heterozygous.xlsx
(89.07 KiB) Downloaded 245 times
meninonas
 
Posts: 137
Joined: Tue Jun 24, 2014 3:25 pm

DREAM 3 Challenge 4

Postby meninonas » Thu Nov 13, 2014 1:08 am

Dr. Yoo,

The goal of the in silico challenges is the reverse engineering of gene networks from steady state and time series data and to predict the directed unsigned network topology from the given in silico generated gene expression datasets. There are three in-silico challenges corresponding to gene networks with 10, 50, and 100 genes.

For every network, the following experiments are simulated:

Heterozygous knock-down. The files -heterozygous contain the steady state levels for the wild-type and the heterozygous knock-down strains for each gene.

Null-mutants. The files -null-mutants contain the steady state levels for the wild-type and the null-mutant strains for each gene.

Trajectories. The files -trajectories contain time courses of the network recovering from several external perturbations. For the networks of size 50, the same number of time courses as in the DREAM2 in silico challenge are provided (23 different perturbations).

The Gold Standard simply states the presence of a relationship, not the direction.
Attachments
InSilicoSize50-Yeast3-trajectories.xlsx
(462.65 KiB) Downloaded 242 times
InSilicoSize50-Yeast3-null-mutants.xlsx
(88.82 KiB) Downloaded 243 times
InSilicoSize50-Yeast3-heterozygous.xlsx
(88.9 KiB) Downloaded 250 times
meninonas
 
Posts: 137
Joined: Tue Jun 24, 2014 3:25 pm

DREAM 3 Challenge 4

Postby meninonas » Thu Nov 13, 2014 1:10 am

Dr. Yoo,

The goal of the in silico challenges is the reverse engineering of gene networks from steady state and time series data and to predict the directed unsigned network topology from the given in silico generated gene expression datasets. There are three in-silico challenges corresponding to gene networks with 10, 50, and 100 genes.

For every network, the following experiments are simulated:

Heterozygous knock-down. The files -heterozygous contain the steady state levels for the wild-type and the heterozygous knock-down strains for each gene.

Null-mutants. The files -null-mutants contain the steady state levels for the wild-type and the null-mutant strains for each gene.

Trajectories. The files -trajectories contain time courses of the network recovering from several external perturbations. For the networks of size 100, they give 46 perturbations (each one with 21 time points).

The Gold Standard simply states the presence of a relationship, not the direction.
Attachments
InSilicoSize100-Ecoli1-trajectories.xlsx
(1.77 MiB) Downloaded 233 times
InSilicoSize100-Ecoli1-null-mutants.xlsx
(320.36 KiB) Downloaded 240 times
InSilicoSize100-Ecoli1-heterozygous.xlsx
(320.83 KiB) Downloaded 255 times
meninonas
 
Posts: 137
Joined: Tue Jun 24, 2014 3:25 pm

DREAM 3 Challenge 4

Postby meninonas » Thu Nov 13, 2014 1:10 am

Dr. Yoo,

The goal of the in silico challenges is the reverse engineering of gene networks from steady state and time series data and to predict the directed unsigned network topology from the given in silico generated gene expression datasets. There are three in-silico challenges corresponding to gene networks with 10, 50, and 100 genes.

For every network, the following experiments are simulated:

Heterozygous knock-down. The files -heterozygous contain the steady state levels for the wild-type and the heterozygous knock-down strains for each gene.

Null-mutants. The files -null-mutants contain the steady state levels for the wild-type and the null-mutant strains for each gene.

Trajectories. The files -trajectories contain time courses of the network recovering from several external perturbations. For the networks of size 100, they give 46 perturbations (each one with 21 time points).

The Gold Standard simply states the presence of a relationship, not the direction.
Attachments
InSilicoSize100-Ecoli2-trajectories.xlsx
(1.78 MiB) Downloaded 252 times
InSilicoSize100-Ecoli2-null-mutants.xlsx
(320.48 KiB) Downloaded 234 times
InSilicoSize100-Ecoli2-heterozygous.xlsx
(321.01 KiB) Downloaded 228 times
meninonas
 
Posts: 137
Joined: Tue Jun 24, 2014 3:25 pm

DREAM 3 Challenge 4

Postby meninonas » Thu Nov 13, 2014 1:14 am

Dr. Yoo,

The goal of the in silico challenges is the reverse engineering of gene networks from steady state and time series data and to predict the directed unsigned network topology from the given in silico generated gene expression datasets. There are three in-silico challenges corresponding to gene networks with 10, 50, and 100 genes.

For every network, the following experiments are simulated:

Heterozygous knock-down. The files -heterozygous contain the steady state levels for the wild-type and the heterozygous knock-down strains for each gene.

Null-mutants. The files -null-mutants contain the steady state levels for the wild-type and the null-mutant strains for each gene.

Trajectories. The files -trajectories contain time courses of the network recovering from several external perturbations. For the networks of size 100, they give 46 perturbations (each one with 21 time points).

The Gold Standard simply states the presence of a relationship, not the direction.
Attachments
InSilicoSize100-Yeast1-trajectories.xlsx
(1.78 MiB) Downloaded 237 times
InSilicoSize100-Yeast1-null-mutants.xlsx
(320.76 KiB) Downloaded 232 times
InSilicoSize100-Yeast1-heterozygous.xlsx
(321.38 KiB) Downloaded 247 times
meninonas
 
Posts: 137
Joined: Tue Jun 24, 2014 3:25 pm

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