Hypothesis: Aberrant genetic and Epigenetic regulation of NRF1 and its targets genes contributes to the pathogenesis of aggressive breast cancer via perturbation of diverse mitochondrial and extra-mitochondrial functions.
Methods: Expression levels of 2,470 identified NRF1 target genes in a set of approximately 460 patients / tumors will be analyze to determine association with the development of aggressive breast cancer. Data set from CBioPortal will be used, after crossing the results with the list of 2,500 NRF1 target genes to select only the data for these genes. I am uploading the initial data but this will be subject to revision as we review the data for inclusion criteria and missing values.