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Changwon Yoo, S.M., Ph.D., PI

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genes of interest

Relaxin, a small peptide hormone of the insulin/relaxin family, demonstrated antifibrotic, organ protective, vasodilatory, and proangiogenic properties in clinical trials and several animal models of human diseases.
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genes of interest

Postby brriva » Fri Dec 15, 2017 9:34 am

CXCL8
COL3A1
IRAK2
TNFAIP3
IL6
COL6A3
NFKB2
MMP1
ACTA2
CAV1
PDGFRB
IL1B
PDGFRA
COL1A2
COL1A1
IGFBP3
NFIB
INHBB
NOG
WNT7B
Last edited by brriva on Fri Dec 15, 2017 10:00 am, edited 1 time in total.
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Re: Some genes of interest

Postby brriva » Fri Dec 15, 2017 9:48 am

As discussed, our aim is to understand the antifibrotic properties of our compound. Gene set analysis, gene ontology and pathways analysis would be a good start. The above is an abbreviated list which includes genes encoding extracellular matrix, ECM-associated proteins (collagens, etc.) and others whose accumulation is characteristic of fibrosis. By no means should this list be considered all-inclusive.
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