Attached are two heat-maps generated from R concerning a dataset from this manuscript
Identification of epigenetic regulators in the array data from the paper, Stem Cell Reports. 2015 Oct 20 Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells.
http://www.sciencedirect.com/science/ar ... 111500274XThe idea was to see if there is any potential interaction with the Polycomb Complex (PRC2) with IdHP ID3 over-expressing hematopoetic cells vs. control genes.
1) I used the genes from that dataset (IdHP ID3 over-expressing hematopoetic cells vs. control) that were involved in the Polycomb Complex (PRC2) such as EZH1, EZH2, EED, SUZ12, and the key gene ID3
2) I came across a review that was published in Nature (2011) about how although the core of the complex is EZH1/2, SUZ12, EED, and RBAP46/48 it does however have more genes with various functions such as AEBP2, PCLs, and JARID2. Furthermore it also has ones that interact with the PRC2 (DNMTs, HDAC1, and SIRT1) but their effect on the PRC2 is unclear so I furthermore used this in the second heat-map generated.
Thank you